Stat1蛋白在急性髓系细胞白血病患者外周血白细胞中的激活

doi:10.3969/j.issn.1004-616x.2004.04.008

癌变·畸变·突变 ›› 2004, Vol. 16 ›› Issue (4): 214-216.doi: 10.3969/j.issn.1004-616x.2004.04.008

Stat1蛋白在急性髓系细胞白血病患者外周血白细胞中的激活

刘　峰，陈元玉，李冠武, 温博贵

汕头大学医学院第二附属医院，广东汕头　515031

收稿日期:2004-03-09 修回日期:2004-06-01 出版日期:2004-07-30 发布日期:2004-07-30
通讯作者: 李冠武

Activation of the Stat1 Protein in the Peripheral Blood White Cells of the Patients with Acute Myeloid Leukemia

LIU Feng, CHEN Yuan-yu, LI Guan-wu, et al

The Second affiliated hospital, Shantou University Medical College，Shantou,515041 China

Received:2004-03-09 Revised:2004-06-01 Online:2004-07-30 Published:2004-07-30
Contact: 李冠武

摘要/Abstract

摘要： 背景与目的：了解急性髓系细胞白血病外周血白细胞Stat1蛋白表达情况，探讨Stat1蛋白的作用区域及与核基质的相互关系。材料与方法：用免疫印迹法检测急性髓系细胞白血病外周血白细胞中Stat1蛋白的表达；结果：在41例急性髓系细胞白血病外周血白细胞中，Stat1激活的阳性率为53.7 ％，正常对照15例阳性率为0 ％。激活的Stat1蛋白转移到细胞核内并与核基质结合；结论： Stat1蛋白在急性髓系细胞白血病外周血白细胞中有异常激活，并与核基质结合，可能通过核基质蛋白发挥作用。

关键词: 急性髓系细胞白血病, Stat1蛋白, 核基质

Abstract: BACKGROUND ＆ AIM： To learn the expression and activation of Stat1 protein in the peripheral blood white cells of acute myeloid leukemia(AML) by combing to the nuclear matrix. MATERIAL AND METHODS: The Stat1 activation were detected by western blot with anti-Stat1 antibody. RESULT:The results showed that Stat1 was activated in the 22/41(53.7 ％) with AML and 0 ％ in the 15 normal controls, and activated Stat1 existed in the nuclear matrix components. CONCLUSION: The conclusion denotes that over expression and activation of Stat1 maybe play an important role in the process of AML by attaching to nuclear matrix .

Key words: acute myeloid leukemia, Stat1 protein, nuclear matrix

刘　峰, 陈元玉, 李冠武, 温博贵. Stat1蛋白在急性髓系细胞白血病患者外周血白细胞中的激活[J]. 癌变·畸变·突变, 2004, 16(4): 214-216.

LIU Feng, CHEN Yuan-yu, LI Guan-wu, et al. Activation of the Stat1 Protein in the Peripheral Blood White Cells of the Patients with Acute Myeloid Leukemia[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2004, 16(4): 214-216.

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Stat1蛋白在急性髓系细胞白血病患者外周血白细胞中的激活

Activation of the Stat1 Protein in the Peripheral Blood White Cells of the Patients with Acute Myeloid Leukemia

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